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The movie centers on Elliot and Beverly Mantle, identical twins and gynecologists who frequently sub for each another professionally and even personally by sharing one another's lovers. They take full advantage of the fact that nobody can tell them apart, until their relationship begins to deteriorate over a woman.
Impeccably executed, Cronenberg's first masterpiece is an unsettling film in which biological horror is entirely conveyed through pyschological exploration of character, masterfully played by Jeremy Irons in the best performance of his career.
People like myself who find the character played by [Genevieve] Bujold (in one of her best performances) more interesting than either of the twins are bound to feel rather frustrated by the end.
In a weird variation of the Dr. Jekyll and Mr. Hyde theme, the Mantles are drawn relentlessly and frighteningly towards an inevitable and appalling fate.
An intense psychological drama which confronts [Cronenberg's] familiar preoccupations -- fear of physical and mental disintegration, mortality, the power struggle between the sexes -- without the paradoxical protection of visceral disgust.
Cronenberg, who has begun to emerge as a master of body-related horrific fantasy, clearly understands that a small amount of medical mischief can be more unnerving than conventional grisliness.